Opportunities and challenges in targeted therapy and immunotherapy for pancreatic cancer

D Cao, Q Song, J Li, Y Jiang, Z Wang… - Expert reviews in …, 2021 - cambridge.org
Pancreatic cancer is one of the most malignant tumours with a poor prognosis. In recent
years, the incidence of pancreatic cancer is on the rise. Traditional chemotherapy and …

[HTML][HTML] The heterogeneity of the tumor microenvironment as essential determinant of development, progression and therapy response of pancreatic cancer

Group Young Researchers in Inflammatory … - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest
cancers in western countries. It is commonly diagnosed at advanced stages and most anti …

[HTML][HTML] The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation

R Yang, X Liang, H Wang, M Guo, H Shen, Y Shi… - …, 2021 - thelancet.com
Background Pancreatic cancer (PC) is one of the most lethal solid malignancies in the world
due to its excessive cell proliferation and aggressive metastatic features. Emerging …

[HTML][HTML] Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival

Y Geng, R Guan, W Hong, B Huang, P Liu… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background N6-methyladenosine (m6A) modification holds an important position in
tumorigenesis and metastasis because it can change gene expression and even function in …

[HTML][HTML] Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer

DD Zhou, WQ Bai, XT Zhai, LP Sun, YS Zhen… - Military Medical …, 2021 - Springer
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype and
occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its …

EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

M Xie, Q Zhang, Y Guo, L Zhu, X Zhu, C Zhang - Nano Research, 2024 - Springer
Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy
and mortality rates, which are largely attributed to the insensitivity of current clinical …

[HTML][HTML] Unravelling the Triad of Lung Cancer, Drug Resistance, and Metabolic Pathways

P Mohanty, B Pande, R Acharya, L Bhaskar, HK Verma - Diseases, 2024 - mdpi.com
Lung cancer, characterized by its heterogeneity, presents a significant challenge in
therapeutic management, primarily due to the development of resistance to conventional …

Targeted Fluorescence Imaging and Anti-Tumor Effects of QDs-NGR Nanoparticles on Pancreatic Cancer Cells

G Tan, B Li, YJ Zhang, RY Zhang… - Science of Advanced …, 2021 - ingentaconnect.com
With a poor prognosis and lack of effective therapies, pancreatic cancer is one of the most
deadly tumors. The early diagnosis of pancreatic cancer is particularly important to improve …

Therapeutic targeting of glutamine metabolism in colorectal cancer

YK Ratre, HK Verma, A Mehta, VK Soni… - Colon Cancer Diagnosis …, 2021 - Springer
Colorectal cancer is one of the most commonly diagnosed incurable multifactorial
malignancies in the world. To date, there are no promising noninvasive therapeutic tools that …

[PDF][PDF] Molecular underpinnings of circadian mechanism, chronotherapy and lung cancer: a mini-review

JP Choudhary, T Sahu, B Pande - Polymorphism, 2022 - researchgate.net
Humans adjust to the diurnally varying light-dark cycle in nature through circadian rhythm, a
phenomenon of about 24 hour oscillations in biological processes. The circadian rhythm …