Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against
cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and …

The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage
polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) …

BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

Recent research in the field of osteoarthritis (OA) has focused on understanding the
underlying molecular and clinical phenotypes of the disease. This narrative review article …

Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate
chains that endow articular cartilage with its ability to withstand compressive loads. It is …

OBJECTIVE: The role of inflammation in osteoarthritis (OA) pathogenesis is unclear, and the
associations between inflammatory cytokines and cartilage loss have not been reported. We …

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends
have shifted from acute effects towards the long-term morbidity of COVID-19. In this review …