Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
DNA repair deficiency regulates immunity response in cancers: molecular mechanism and approaches for combining immunotherapy
Y Xu, S Nowsheen, M Deng - Cancers, 2023 - mdpi.com
Simple Summary DNA repair pathways play a crucial role in maintaining the stability of a
cell's genetic material. When these pathways are defective, it can lead to genomic instability …
cell's genetic material. When these pathways are defective, it can lead to genomic instability …
APE1-dependent base excision repair of DNA photodimers in human cells
A Gautam, H Fawcett, K Burdova, J Brazina… - Molecular Cell, 2023 - cell.com
UV irradiation induces" bulky" DNA photodimers such as (6-4)-photoproducts and
cyclobutane pyrimidine dimers that are removed by nucleotide excision repair, a complex …
cyclobutane pyrimidine dimers that are removed by nucleotide excision repair, a complex …
Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes
The antitumor activity of poly (ADP-ribose) polymerase inhibitors (PARPis) has been
ascribed to PARP trapping, which consists in tight DNA–protein complexes. Here we …
ascribed to PARP trapping, which consists in tight DNA–protein complexes. Here we …
Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all'solution
Cells constantly accumulate mutations, which are caused by replication errors, as well as
through the action of endogenous and exogenous DNA-damaging agents. Mutational …
through the action of endogenous and exogenous DNA-damaging agents. Mutational …
XRCC1 counteracts poly (ADP ribose) polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal …
Base excision repair (BER) removes damaged bases by generating single‐strand breaks
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
(SSBs), gap‐filling by DNA polymerase β (POLβ), and resealing SSBs. A base‐damaging …
Cross-species investigation into the requirement of XPA for nucleotide excision repair
After reconstitution of nucleotide excision repair (excision repair) with XPA, RPA, XPC, TFIIH,
XPF-ERCC1 and XPG, it was concluded that these six factors are the minimal essential …
XPF-ERCC1 and XPG, it was concluded that these six factors are the minimal essential …
Synthesis of methoxy-, methylenedioxy-, hydroxy-, and halo-substituted benzophenanthridinone derivatives as DNA topoisomerase IB (TOP1) and tyrosyl-DNA …
DX Hu, WL Tang, Y Zhang, H Yang… - Journal of medicinal …, 2021 - ACS Publications
As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1)
removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can …
removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can …
Lignin nanoparticles deliver novel thymine biomimetic photo-adducts with antimelanoma activity
S Gabellone, D Piccinino, S Filippi… - International Journal of …, 2022 - mdpi.com
We report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane
spacer between nucleobases and characterized by antimelanoma activity against two …
spacer between nucleobases and characterized by antimelanoma activity against two …
PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1
Persistent DNA-protein crosslinks formed by human topoisomerase IIIα (TOP3A-DPCs)
interfere with DNA metabolism and lead to genome damage and cell death. Recently, we …
interfere with DNA metabolism and lead to genome damage and cell death. Recently, we …