ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …

Novel inhaled therapeutics including antibiotics, vaccines and anti-hypertensives, have led
to innovations in designing suitable delivery systems. These emerging design technologies …

Pulmonary drug delivery is the focus of much research and development because of its
great potential to produce maximum therapeutic benefit. Among the available options the dry …

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …

With the rapid growth of the nanotechnology industry, the need to understand the biological
effects of aerosol exposure has become increasingly important. Featuring contributions by …

Purpose Deposition characteristics of MDI and DPI aerosols were compared throughout the
conducting airways for the first time using a combination of in vitro experiments and a newly …

Objectives In this review paper, we explore the interaction between the functioning
mechanism of different nebulizers and the physicochemical properties of the formulations for …

Purpose CFD provides a powerful approach to evaluate the deposition of pharmaceutical
aerosols; however, previous studies have not compared CFD results of deposition …

This article reviews recent developments in computational modeling of dry powder inhalers
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …