Liver diseases in the Asia-Pacific region: a lancet gastroenterology & hepatology commission

SK Sarin, M Kumar, M Eslam, J George… - The lancet …, 2020 - thelancet.com
Summary The Asia-Pacific region is home to more than half of the global population and
accounted for 62· 6% of global deaths due to liver diseases in 2015. 54· 3% of global deaths …

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

[HTML][HTML] Recent advances in lean NAFLD

R Xu, J Pan, W Zhou, G Ji, Y Dang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
As the predominant type of chronic liver disease, the growing prevalence of nonalcoholic
fatty liver disease (NAFLD) has become a concern worldwide. Although obesity plays the …

The global NAFLD epidemic

R Loomba, AJ Sanyal - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the
liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty …

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

RJ Perry, VT Samuel, KF Petersen, GI Shulman - Nature, 2014 - nature.com
Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

The upstream pathway of mTOR-mediated autophagy in liver diseases

H Wang, Y Liu, D Wang, Y Xu, R Dong, Y Yang, Q Lv… - Cells, 2019 - mdpi.com
Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

Epidemiology and natural history of non-alcoholic fatty liver disease

Y Fazel, AB Koenig, M Sayiner, ZD Goodman… - Metabolism, 2016 - Elsevier
Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver
disease (NAFLD) that leads to progressive liver disease and presents a growing challenge …

Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study

R Kwok, KC Choi, GLH Wong, Y Zhang, HLY Chan… - Gut, 2016 - gut.bmj.com
Objective Type 2 diabetes is an important risk factor for non-alcoholic fatty liver disease
(NAFLD), but current guidelines provide conflicting recommendations on whether diabetic …

[HTML][HTML] Non-alcoholic fatty liver disease: The diagnosis and management

SM Abd El-Kader… - World journal of …, 2015 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease that
occurs across all age groups and is recognized to occur in 14%-30% of the general …

Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective …

Y Eguchi, H Hyogo, M Ono, T Mizuta, N Ono… - Journal of …, 2012 - Springer
Background The prevalence of nonalcoholic fatty liver disease (NAFLD) has been
increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the …