Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

A dysregulated host response is a common feature in critically ill patients due to both
infectious and non-infectious origins that can lead to life-threatening organ dysfunction …

There is a clinical need for conceptually new treatments that target the excessive activation
of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides …

Sustainable health service delivery plays a vital role for the development of countries.
Sustainability of health services is associated with many factors. One of these factors is …

Energy costs have become a very important problem for businesses, especially in recent
years. As a result of these high costs, businesses may experience financial problems. If this …

Background Lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios have
been implicated in predicting mortality in sepsis patients. However, their prognostic value …

Sepsis is a high‐incidence disease and demands intensive care. Finding effective treatment
is the key to cure sepsis. Studies have shown a lower level of vitamin C in patients with …

Abstract Objective Systematic reviews (SRs) offer updated evidence to support decision-
making on sepsis treatments. However, the rigour of SRs may vary, and methodological …

Background: The precise diagnostic and prognostic biological markers were needed in
immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in …

Objective Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)
modulates the inflammatory immune response and organ dysfunction, which are closely …