Systems vaccinology has proven a fascinating development in the last decade. Where
traditionally vaccine development has been dominated by trial and error, systems …

Neither immunization nor recovery from natural infection provides life-long protection
against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an …

A vaccine based on outer membrane vesicles of pertussis (omvPV) is protective in a mouse-
challenge model and induces a broad antibody and mixed Th1/Th2/Th17 response against …

BPZE1 is a live attenuated Bordetella pertussis vaccine for nasal administration to mimic the
natural route of infection. Here, we studied the mechanism of BPZE1-induced immunity in …

Worldwide resurgence of whooping cough calls for improved, next-generation pertussis
vaccines that induce broad and long-lasting immunity. A mucosal pertussis vaccine based …

Mucosal immunity is often required for protection against respiratory pathogens but the
underlying cellular and molecular mechanisms of induction remain poorly understood. Here …

Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-
emerging worldwide despite high vaccination coverage. The causative agent of this disease …

Pertussis is a severe respiratory tract infection caused by Bordetella pertussis. This
bacterium infects the ciliated epithelium of the human airways. We investigated the epithelial …

Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We
previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to …

Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs)
has gained considerable attention due to their crucial role in regulating immunity and tissue …