Targeting autophagy in cancer

JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …

Acetyl-CoA metabolism and histone acetylation in the regulation of aging and lifespan

PC Bradshaw - Antioxidants, 2021 - mdpi.com
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Transcriptional and epigenetic regulation of autophagy in aging

LR Lapierre, C Kumsta, M Sandri, A Ballabio… - Autophagy, 2015 - Taylor & Francis
Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …

Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective

TB López-Méndez, M Sánchez-Álvarez, F Trionfetti… - Cell & bioscience, 2023 - Springer
In recent years, progress in nanotechnology provided new tools to treat cancer more
effectively. Advances in biomaterials tailored for drug delivery have the potential to …

Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis

P Mistry, MJ Kaplan - Clinical Immunology, 2017 - Elsevier
Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury

B He, Y Zhao, L Xu, L Gao, Y Su… - Journal of pineal …, 2016 - Wiley Online Library
Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin
increases ischemic heart disease risk. The nuclear melatonin receptors ROR s are pivotally …

Autophagy—cell survival and death

X Yan, R Zhou, Z Ma - Autophagy: Biology and Diseases: Basic Science, 2019 - Springer
Autophagy, which is one of the most important ways to maintain cell homeostasis plays an
important regulatory role in cell survival and death. Currently, it is agreed that autophagy …

Autophagy, oxidative stress and cancer development

E Taucher, I Mykoliuk, M Fediuk, FM Smolle-Juettner - Cancers, 2022 - mdpi.com
Simple Summary Autophagy, as an important cellular repair mechanism, is important for the
prevention of several diseases, including metabolic and neurologic disorders, and cancer …

Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells

TW Kim - Acta Pharmacologica Sinica, 2022 - nature.com
Previous reports suggested that cinnamaldehyde (CA), the bioactive ingredient in
Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities …

Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

JF Moruno-Manchon, P Lejault, Y Wang, B McCauley… - Elife, 2020 - elifesciences.org
Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA)
structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we …