Plants alter their morphology and cellular homeostasis to promote resilience under a variety
of heat regimes. Molecular processes that underlie these responses have been intensively …

Cells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as
during cell division, growth, migration and cell death. Mammalian cells adjust their volume …

Mechanosensitive ion channels are force-transducing enzymes that couple mechanical
stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is …

INTRODUCTION Along with its well-documented role as a track for cargo transport, the
microtubule (MT) cytoskeleton is linked to diverse structural and signaling roles in the …

How metazoan mechanotransduction channels sense mechanical stimuli is not well
understood. The NOMPC channel in the transient receptor potential (TRP) family, a …

In humans, the TRP superfamily of cation channels includes 27 related molecules that
respond to a remarkable variety of chemical and physical stimuli. While physiological roles …

Environmental adaptation of organisms relies on fast perception and response to external
signals, which lead to developmental changes. Plant cell growth is strongly dependent on …

The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

At its most fundamental level, touch sensation requires the translation of mechanical energy
into mechanosensitive ion channel opening, thereby generating electro-chemical signals …

Piezo channels are a ubiquitously expressed, principal type of molecular force sensor in
eukaryotes. They enable cells to decode a myriad of physical stimuli and are essential …