The members of the mechanistically diverse enolase superfamily catalyze different overall
reactions. Each shares a partial reaction in which an active site base abstracts the α-proton …

α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes a key chiral inversion step in the
metabolism of branched-chain fatty acids, ibuprofen and related drugs. Protein levels are …

The viability of living systems requires that C H bonds of biological molecules be stable in
water, but that there also be a mechanism for shortening the timescale for their heterolytic …

Mandelate racemase (MR) catalyses the Mg2+-dependent interconversion of (R)-and (S)-
mandelate. To effect catalysis, MR stabilizes the altered substrate in the transition state (TS) …

Mandelate racemase (EC 5.1. 2.2) from Pseudomonas putida catalyzes the interconversion
of the two enantiomers of mandelic acid with remarkable proficiency, producing a rate …

o-Carbonyl arylboronic acids such as 2-formylphenylboronic acid (2-FPBA) are employed in
biocompatible conjugation reactions with the resulting iminoboronate adduct stabilized by …

Mandelate racemase (EC 5.1. 2.2) from Pseudomonas putida catalyzes the interconversion
of the two enantiomers of mandelic acid with remarkable proficiency, stabilizing the altered …

Mandelate racemase (MR, EC 5.1. 2.2) from Pseudomonas putida catalyzes the Mg2+-
dependent 1, 1-proton transfer that interconverts the enantiomers of mandelate and has …

Chiral, non-racemic α-hydroxyphosphonates have been prepared in high enantiomeric
excess (96–98% ee), via stereoselective oxaziridine-mediated hydroxylation of diallyl …

2, 2-Bis (4-isobutylphenyl) propanoyl-CoA and 2, 2-bis (4-t-butylphenyl) propanoyl-CoA are
rationally designed, gem-disubstituted substrate–product analogues that competitively …