The four Janus kinase (JAK) proteins and seven signal transducer and activator of
transcription (STAT) transcription factors mediate intracellular signal transduction …

The COVID-19 pandemic has brought challenges for people with rheumatic disease in
addition to those faced by the general population, including concerns about higher risks of …

Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized
by adaptive immune system activation, formation of double-stranded DNA autoantibodies …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge
of circulating immune cell types and states associated with SLE remains incomplete. We …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Clinical heterogeneity, unpredictable course and flares are characteristics of systemic lupus
erythematosus (SLE). Although SLE is—by and large—a systemic disease, occasionally it …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Objective To assess the efficacy and safety of deucravacitinib, an oral, selective, allosteric
inhibitor of TYK2, in a phase II trial in adult patients with active systemic lupus erythematosus …

Background Antibody-binding of blood dendritic cell antigen 2 (BDCA2), which is expressed
exclusively on plasmacytoid dendritic cells, suppresses the production of type I interferon …

Background Blood dendritic cell antigen 2 (BDCA2) is a receptor that is exclusively
expressed on plasmacytoid dendritic cells, which are implicated in the pathogenesis of …