Astrocytic TRPV4 channels and their role in brain ischemia
J Tureckova, Z Hermanova, V Marchetti… - International Journal of …, 2023 - mdpi.com
Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …
selective cation channels expressed in different cell types of the central nervous system …
Ion channel dysfunction in astrocytes in neurodegenerative diseases
S Wang, B Wang, D Shang, K Zhang, X Yan… - Frontiers in …, 2022 - frontiersin.org
Astrocytes play an important role in the central nervous system (CNS). Ion channels in these
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …
Functional role of coupling the endothelial TRPV4 and KCa3.1 channels in regulating coronary vascular tone
A Mao, D He, K Zhang, M Gao, H Kan… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose High‐fat diet (HFD) induces dysregulated pathways in coronary
artery endothelial cells (CAECs), which leads to altered regulation of vascular tone, tissue …
artery endothelial cells (CAECs), which leads to altered regulation of vascular tone, tissue …
Ion Channels and Ionotropic Receptors in Astrocytes: Physiological Functions and Alterations in Alzheimer's Disease and Glioblastoma
The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …
[HTML][HTML] KCa3. 1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway
T Wei, Y Wang, W Xu, Y Liu, H Chen, Z Yu - Neurobiology of Disease, 2019 - Elsevier
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in
neurodegenerative disorders. The calcium-activated potassium channel (KCa3. 1) is active …
neurodegenerative disorders. The calcium-activated potassium channel (KCa3. 1) is active …
Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling
Z Yu, F Dou, Y Wang, L Hou, H Chen - Journal of Neuroinflammation, 2018 - Springer
Abstract Background The intermediate-conductance Ca 2+-activated K+ channel KCa3. 1
was recently shown to control the phenotype switch of reactive astrogliosis (RA) in …
was recently shown to control the phenotype switch of reactive astrogliosis (RA) in …
Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II‐infused hypertensive mice
Hypertension is an important contributor to cognitive decline but the underlying mechanisms
are unknown. Although much focus has been placed on the effect of hypertension on …
are unknown. Although much focus has been placed on the effect of hypertension on …
The potassium channel KCa3. 1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson's disease
J Lu, F Dou, Z Yu - Journal of Neuroinflammation, 2019 - Springer
Background Recent studies described a critical role for microglia in Parkinson's disease
(PD), where these central nerve system resident immune cells participate in the …
(PD), where these central nerve system resident immune cells participate in the …
Megalencephalic leukoencephalopathy with subcortical cysts protein-1 (MLC1) counteracts astrocyte activation in response to inflammatory signals
MS Brignone, A Lanciotti, B Serafini, C Mallozzi… - Molecular …, 2019 - Springer
Megalencephalic leukoencephalopathy with subcortical cysts protein-1 (MLC1) is a
membrane protein expressed by perivascular astrocytes. MLC1 mutations cause MLC, an …
membrane protein expressed by perivascular astrocytes. MLC1 mutations cause MLC, an …
Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation
G She, MC Hou, Y Zhang, Y Zhang, Y Wang… - …, 2020 - Am Heart Assoc
Heart failure is associated with sympatho-βAR (β-adrenoceptor) activation and cardiac
fibrosis. Gal-3 (galectin-3) and KCa3. 1 channels that are upregulated in diverse cells of …
fibrosis. Gal-3 (galectin-3) and KCa3. 1 channels that are upregulated in diverse cells of …