Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …

Astrocytes play an important role in the central nervous system (CNS). Ion channels in these
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …

Background and Purpose High‐fat diet (HFD) induces dysregulated pathways in coronary
artery endothelial cells (CAECs), which leads to altered regulation of vascular tone, tissue …

The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …

Neuroinflammation may induce a phenotype switch to reactive astrogliosis in
neurodegenerative disorders. The calcium-activated potassium channel (KCa3. 1) is active …

Abstract Background The intermediate-conductance Ca 2+-activated K+ channel KCa3. 1
was recently shown to control the phenotype switch of reactive astrogliosis (RA) in …

Hypertension is an important contributor to cognitive decline but the underlying mechanisms
are unknown. Although much focus has been placed on the effect of hypertension on …

Background Recent studies described a critical role for microglia in Parkinson's disease
(PD), where these central nerve system resident immune cells participate in the …

Megalencephalic leukoencephalopathy with subcortical cysts protein-1 (MLC1) is a
membrane protein expressed by perivascular astrocytes. MLC1 mutations cause MLC, an …

Heart failure is associated with sympatho-βAR (β-adrenoceptor) activation and cardiac
fibrosis. Gal-3 (galectin-3) and KCa3. 1 channels that are upregulated in diverse cells of …