High arsenic (As) levels in food and drinking water, or under some occupational conditions,
can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to …

Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites
of the genus Trypanosoma, transmitted by the tsetse fly. The disease has two forms …

Arsenicals are one of the oldest treatments for a variety of human disorders. Although
infamous for its toxicity, arsenic is paradoxically a therapeutic agent that has been used …

Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Trypanosomatids differ from. ail other organisms in their abirity to conJugare the-sulfur-
containing tripeptide, glutathio-ne, and the poryaminJ, spermioine, to form trypanothione …

Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and
diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping …

The concept of disease-specific chemotherapy was developed a century ago. Dyes and
arsenical compounds that displayed selectivity against trypanosomes were central to this …

Saccharomyces cerevisiae has two independent transport systems for the removal of
arsenite from the cytosol. Acr3p is a plasma membrane transporter that confers resistance to …

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of
mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS …

Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …