Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

J. Neurochem.(2011) 118, 460–474. Abstract AMP‐activated protein kinase (AMPK)
stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy …

The occurrence of Alzheimer's disease (AD) worldwide has been progressively accelerating
at an alarming rate, without any successful therapeutic strategy for the disease mitigation …

The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting millions
of people worldwide. Apart from age, the major risk factor identified so far for the sporadic …

The strongest known genetic risk factor for the development of late-onset Alzheimer disease
is inheritance of the apolipoprotein (apo) E4 (ε4 allele) although the mechanisms underlying …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of age-related dementia that begins with memory loss and progresses to …

The amyloid precursor protein (APP) is subject to alternative pathways of proteolytic
processing, leading either to production of the amyloid-β (Aβ) peptides or to non …

High-density lipoproteins (HDL) play a key role in cholesterol homeostasis maintenance in
the central nervous system (CNS), by carrying newly synthesized cholesterol from astrocytes …