Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

Background: Benznidazole is effective for treating acute-stage Chagas disease, but its
effectiveness for treating indeterminate and chronic stages remains uncertain. Objective: To …

The susceptibility and natural resistance to two nitroheterocyclic derivatives used clinically in
Chagas disease (nifurtimox and benznidazole) were investigated in 47 Trypanosoma cruzi …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of
Latin America. Although the occurrence of acute cases sharply has declined due to …

Trypanosoma cruzi is the causative agent of Chagas' disease. The major protease, cruzain,
is a target for the development of new chemotherapy. We report the first successful treatment …

The aim of this article is to present an investigation of cure rate, after long follow up, of
specific chemotherapy with benznidazole in patients with both acute and chronic Chagas …

Prescribing etiologic treatment for chronic Chagas' disease is highly controversial because
of the difficulties involved in assessing its therapeutic efficacy—the low degree of …

Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite
infection is endemic in Latin America and presents an increasing clinical challenge due to …