The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and
non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8 …

Many different types of programmed cell death (PCD) have been identified, including
apoptosis and necroptosis. Apoptosis is a type of cell death that is controlled by various …

The molecular mediators of cell death and inflammation in Alzheimer's disease (AD) have
yet to be fully elucidated. Caspase-8 is a critical regulator of several cell death and …

Caspase-8 has been classified as an apoptotic caspase, and its initial definition was an
initiator of extrinsic cell death. During the past decade, the concept of caspase-8 functioning …

Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people
around the world. Plasmodium undergoes obligatory development and replication in the …

Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium
falciparum parasites; it is characterized by the sequestration of infected red blood cells …

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …

Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

BACKGROUND: 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) is an effective anticancer
agent, and when combined with other agents it shows superior activities. Vitamin B12 has …

Gasdermins (GSDMs) are a group of proteins that are cleaved by inflammatory caspases to
induce pore formation in the plasma membrane to cause membrane permeabilization and …