Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement.
Notably, the same pathways governing cell growth, death, and differentiation during the …

Osteoarthritis (OA) is the most common joint disease in the United States, affecting more
than 30 million people, and is characterized by cartilage degeneration in articulating joints …

Osteoarthritis (OA) is a chronic, progressive and degenerative disease, and its incidence is
increasing on a yearly basis. However, the pathological mechanism of OA at each stage is …

Osteochondral junction is a functional unit comprising the articular cartilage, calcified
cartilage, and subchondral bone. Alteration in any component of this composite unit can …

Osteoarthritis (OA), a chronic degenerative disease, is a major cause of pain, disability, and
reduced quality of life among the elderly worldwide. The key to treating it is early prevention …

Crosstalk between subchondral bone and articular cartilage is considered a central feature
of osteoarthritis (OA) initiation and progression, but its underlying molecular mechanism …

Objective To evaluate the dose–response relationship of exercise loading in the cartilage-
subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the …