Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural
active ingredient with various biological activities, such as anti-cancer, anti-inflammatory …

Herbal medicine which involves the use of plants for their medicinal value, dates as far back
as the origin of mankind and demonstrates an array of applications including cardiovascular …

The transcription factor NF-κB is one of the main players involved in inflammatory responses
during which NF-κB becomes rapidly activated. However to maintain homeostasis, this NF …

Purpose: Chronic myelogenous leukemia (CML) is characterized by the constitutive
activation of Bcr-Abl tyrosine kinase. Bcr-Abl-T315I is the predominant mutation that causes …

Natural products have been a great source of many small molecule drugs for various
diseases. In spite of recent advances in biochemical engineering and fermentation …

Pyroptosis has recently been established as a term of programmed-inflammatory cell death.
Pyroptosis is mainly divided into two molecular signaling pathways, including caspase-1 …

Enhancer of zeste homolog 2 (EZH 2) has been characterized as a critical oncogene and a
promising drug target in human malignant tumors. The current EZH 2 inhibitors strongly …

Gambogic acid (GA), a xanthonoid extracted from the resin of the tree, Garcinia hanburyi,
was recently shown to exert anticancer activity in multiple studies, but the underlying action …

Gambogic acid (GA) is a caged xanthone that is derived from Garcinia hanburyi and
functions as a strong apoptotic inducer in many types of cancer cells. The distinct …