Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Bone remodeling consists of resorption by osteoclasts (OCs) and formation by osteoblasts
(OBs). Precise coordination of these activities is required for the resorbed bone to be …

Abstract Background Cochlear implants (CIs) restore hearing to deafened patients. The
foreign body response (FBR) following cochlear implantation (post-CI) comprises an …

Bone regeneration depends on a pool of bone/cartilage stem/progenitor cells and signaling
mechanisms regulating their differentiation. Using in vitro approach, we have shown that …

Endochondral ossification (ECO) is a form of bone formation whereby the newly deposited
bone replaces the cartilage template. A decellularized artificial cartilage graft (dLhCG) …

While sclerostin-neutralizing antibodies (Scl-Abs) transiently stimulate bone formation by
activating Wnt signaling in osteoblast lineage cells, they exert sustained inhibition of bone …

The strictly regulated bone remodeling process ensures that osteoblastic bone formation is
coupled to osteoclastic bone resorption. This coupling is regulated by a panel of coupling …

Estrogen receptor α (ESR1) is involved in E2 signaling and plays a major role in
postmenopausal bone loss. However, the molecular network underlying ESR1 has not been …

Simple Summary The purpose of this study was to analyze differential cell signaling in
response to denosumab treatment to identify and subsequently inhibit molecular targets in …

Osteogenesis imperfecta (OI), or brittle bone disease, is a disorder characterized by bone
fragility and increased fracture incidence. All forms of OI also feature short stature, implying …