The impact of CKD on uremic toxins and gut microbiota

J Rysz, B Franczyk, J Ławiński, R Olszewski… - Toxins, 2021 - mdpi.com
Numerous studies have indicated that the progression of chronic kidney disease (CKD) to
end-stage renal disease (ESRD) is strictly associated with the accumulation of toxic …

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

The gut microbiome, kidney disease, and targeted interventions

A Ramezani, DS Raj - Journal of the American Society of …, 2014 - journals.lww.com
The human gut harbors> 100 trillion microbial cells, which influence the nutrition,
metabolism, physiology, and immune function of the host. Here, we review the quantitative …

[HTML][HTML] Chronic kidney disease alters intestinal microbial flora

ND Vaziri, J Wong, M Pahl, YM Piceno, J Yuan… - Kidney international, 2013 - Elsevier
The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring
trophic and protective functions. Since the biochemical environment shapes the structure …

Serum trimethylamine-N-oxide is elevated in CKD and correlates with coronary atherosclerosis burden

JR Stubbs, JA House, AJ Ocque, S Zhang… - Journal of the …, 2016 - journals.lww.com
Abstract Trimethlyamine-N-oxide (TMAO) was recently identified as a promoter of
atherosclerosis. Patients with CKD exhibit accelerated development of atherosclerosis; …

Role of the gut microbiome in uremia: a potential therapeutic target

A Ramezani, ZA Massy, B Meijers, P Evenepoel… - American Journal of …, 2016 - Elsevier
Also known as the “second human genome,” the gut microbiome plays important roles in
both the maintenance of health and the pathogenesis of disease. The symbiotic relationship …

Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment

ND Vaziri, YY Zhao, MV Pahl - Nephrology Dialysis …, 2016 - academic.oup.com
Chronic kidney disease (CKD) results in systemic inflammation and oxidative stress which
play a central role in CKD progression and its adverse consequences. Although many of the …

Gut microbiome in chronic kidney disease: challenges and opportunities

A Nallu, S Sharma, A Ramezani, J Muralidharan… - Translational …, 2017 - Elsevier
More than 100 trillion microbial cells that reside in the human gut heavily influence nutrition,
metabolism, and immune function of the host. Gut dysbiosis, seen commonly in patients with …

Oxidative stress in ESRD patients on dialysis and the risk of cardiovascular diseases

J Rysz, B Franczyk, J Ławiński, A Gluba-Brzózka - Antioxidants, 2020 - mdpi.com
Chronic kidney disease is highly prevalent worldwide. The decline of renal function is
associated with inadequate removal of a variety of uremic toxins that exert detrimental …

CKD impairs barrier function and alters microbial flora of the intestine: a major link to inflammation and uremic toxicity

ND Vaziri - Current opinion in nephrology and hypertension, 2012 - journals.lww.com
CKD impairs barrier function and alters microbial flora of t... : Current Opinion in Nephrology and
Hypertension CKD impairs barrier function and alters microbial flora of the intestine: a major …