TLR agonists as vaccine adjuvants in the prevention of viral infections: An overview

MEH Kayesh, M Kohara… - Frontiers in …, 2023 - frontiersin.org
Tol-like receptor (TLR) agonists, as potent adjuvants, have gained attention in vaccine
research for their ability to enhance immune responses. This study focuses on their …

Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens

S Ponne, R Kumar, SM Vanmathi, RSN Brilhante… - Vaccine, 2024 - Elsevier
Vaccines have significantly reduced the impact of numerous deadly viral infections.
However, there is an increasing need to expedite vaccine development in light of the …

Computational design of a multi-epitope vaccine candidate against Langya henipavirus using surface proteins

S Ahmad, S Nazarian, A Alizadeh… - Journal of …, 2023 - Taylor & Francis
Abstract In July 2022, Langya henipavirus (LayV) was identified in febrile patients in China.
There is currently no approved vaccine against this virus. Therefore, this research aimed to …

[HTML][HTML] The Role of Mitochondrial Dysfunction in the Development of Acute and Chronic Hepatitis С

A Blagov, V Sukhorukov, V Orekhova… - Frontiers in Bioscience …, 2023 - imrpress.com
Currently, the issue relating to the discussion raised in this article appears to be for what
purposes the hepatitis C virus (HCV) modulates cellular processes, such as antiviral …

Designing multi-epitope vaccine against human cytomegalovirus integrating pan-genome and reverse vaccinology pipelines

R Biswas, RG Swetha, S Basu, A Roy, S Ramaiah… - Biologicals, 2024 - Elsevier
Human cytomegalovirus (HCMV) is accountable for high morbidity in neonates and
immunosuppressed individuals. Due to the high genetic variability of HCMV, current …

A comprehensive immunoinformatic analysis of chitin deacetylase's and MP88 for designing multi-epitope vaccines against Cryptococcus neoformans

MAS Khan, MI Miah, SR Rahman - Journal of Biomolecular …, 2023 - Taylor & Francis
Cryptococcus neoformans causes life-threatening pneumonia and meningitis and is
regarded as one of the leading killers of immunocompromised individuals. There is currently …

Sofosbuvir (+) daclatasvir (+) ribavirin in Egyptian patients with hepatitis C virus: Therapeutic outcomes and the prognostic role of natural killer cells

AB Zaid, SK Almady, SM Awad, MG Elabd… - Current Research in …, 2024 - Elsevier
Background One of the prominent causes of chronic liver disease worldwide is the hepatitis
C virus (HCV). HCV believed that innate immunity contributes to a sustained virological …

In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches

S Ahmad, FM Demneh, B Rehman, TN Almanaa… - International Journal of …, 2024 - Elsevier
Infection with the hepatitis C virus (HCV) is one of the causes of liver cancer, which is the
world's sixth most prevalent and third most lethal cancer. The current treatments do not …

Computational identification of a multi-peptide vaccine candidate in E2 glycoprotein against diverse hepatitis c virus genotypes

S Kumari, A Kessel, D Singhal, G Kaur… - Journal of …, 2023 - Taylor & Francis
Abstract Hepatitis C Virus (HCV) is estimated to affect nearly 180 million people worldwide,
culminating in∼ 0.7 million yearly casualties. However, a safe vaccine against HCV is not …

Unveiling novel anti-viral mechanisms of ε-poly-l-lysine on tobacco mosaic virus-infected Nicotiana tabacum through microRNA and transcriptome sequencing

H Liu, M Yu, S Zhou, Y Wang, Z Xia, Z Wang… - International Journal of …, 2024 - Elsevier
MicroRNAs (miRNAs) play important roles in plant defense against various pathogens. ε-
poly-l-lysine (ε-PL), a natural anti-microbial peptide produced by microorganisms, effectively …