Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the
etiology of cancer pain remains unclear, animal models of cancer pain have allowed …

For many patients, pain is the first sign of cancer and, while pain can be present at any time,
the frequency and intensity of pain tend to increase with advancing stages of the disease …

Abstract Purpose of Review This paper describes recent advances in understanding the
mechanisms that drive fracture pain and how these findings are helping develop new …

To provide a tool to investigate the mechanisms inducing and maintaining cancer-related
pain and hyperalgesia, a soft tissue tumor/metastasis model was developed that is …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Transient receptor potential (TRP) channels are critical receptors in the transduction of
nociceptive stimuli. The microenvironment of diverse types of cancer releases substances …

Pain remains an area of considerable unmet clinical need, and this is particularly true of
pain associated with bone metastases, in part because existing analgesic drugs show only …

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat.
Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely …