Avian reoviruses are important pathogens that cause considerable losses to the poultry
industry, but they have been poorly characterized at the molecular level in the past, mostly …

Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as
sites of viral genome replication and particle assembly. These highly specialized structures …

Mammalian orthoreovirus (MRV) is a double-stranded RNA virus from the Reoviridae family
presenting a promising activity as an oncolytic virus. Recent studies have underlined MRV's …

Viruses require the host translational apparatus to synthesize viral proteins. Host stress
response mechanisms that suppress translation, therefore, represent a significant obstacle …

Viruses are extensively studied as pathogens and exploited as molecular tools and
therapeutic agents. Existing methods to purify viruses such as gradient ultracentrifugation or …

Piscine orthoreovirus (PRV) is associated with heart-and skeletal muscle inflammation
(HSMI) of farmed Atlantic salmon (Salmo salar). We have performed detailed sequence …

Mammalian reoviruses are pathogens that cause gastrointestinal and respiratory infections.
In humans, the mammalian reoviruses usually cause mild or subclinical disease, and they …

Abstract Background Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in
vitro, in in vivo murine models and in early clinical trials. However the true potential of …

Myocarditis is indicated as the second leading cause of sudden death in young adults.
Reovirus induces myocarditis in neonatal mice, providing a tractable model system for …

Among members of the genus Orthoreovirus, family Reoviridae, a group of non-enveloped
viruses with genomes comprising ten segments of double-stranded RNA, only the “non …