Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD: 1: CB1:),
cloned in 1990, and CB2 (2.1: CBD: 2: CB2:), cloned in 1993. Distinction between these …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Recent advances in the understanding of brain cannabinoid receptor function have renewed
interest in the association between cannabinoid compounds and psychosis. In a 3-day …

What is known and objective: Cannabidiol (CBD) is the main non-psychotropic component
of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia …

Rationale Cannabis is one of the most frequently used substances. Cannabis and its
constituent cannabinoids are known to impair several aspects of cognitive function, with the …

There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G
proteins. CB1 receptors exist primarily on central and peripheral neurons, one of their …

Behavioural and pharmacological effects of Δ9‐tetrahydrocannabinol (THC) and nicotine
are well known. However, the possible interactions between these two drugs of abuse …

The CB 1 cannabinoid receptor is widely distributed in the central and peripheral nervous
system. Within the neuron, the CB 1 receptor is often localised in axon terminals, and its …

In order to explore potential therapeutic implications of cannabinoid antagonists, the effects
of the prototypical cannabinoid antagonist SR141716A on monoamine efflux from the …

Recreational and chronic cannabis use has been associated with a range of acute and
chronic effects including; anti‐nociceptive actions, anxiety, depression, psychotic symptoms …