For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Abstract p53, encoded by the tumor suppressor gene TP53, is one of the most important
tumor suppressor factors in vivo and can be negatively regulated by MDM2 through p53 …

Apoptosis is a form of programmed cell death that is mediated by intrinsic and extrinsic
pathways. Dysregulation of and resistance to cell death are hallmarks of cancer. For over …

Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular
turnover. While these two pathways are distinct, they can also regulate each other, and …

Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy,
including the treatment of glioblastoma (GB). In response to cellular stressors, such as DNA …

Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53
activity has become one of the most appealing anticancer therapeutic strategies. Here, we …

Simple Summary p53 is best known for its tumour suppressive functions mediated through
regulation of an extensive-gene regulatory network. Here we review progress in our …

The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers.
Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of …

The master tumor suppressor p53 regulates multiple cell fate decisions, such as cell cycle
arrest and apoptosis, via transcriptional control of a broad gene network. Dysfunction in the …

Background More than half of mesothelioma tumours show alterations in the tumour
suppressor gene BAP1. BAP1-deficient mesothelioma is shown to be sensitive to EZH2 …