[HTML][HTML] Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers

R Mallick, S Basak, AK Duttaroy - Progress in lipid research, 2021 - Elsevier
The dysregulation of fat metabolism is involved in various disorders, including
neurodegenerative, cardiovascular, and cancers. The uptake of long-chain fatty acids …

Discerning molecular interactions: a comprehensive review on biomolecular interaction databases and network analysis tools

SK Miryala, A Anbarasu, S Ramaiah - Gene, 2018 - Elsevier
Computational analysis of biomolecular interaction networks is now gaining a lot of
importance to understand the functions of novel genes/proteins. Gene interaction (GI) …

[HTML][HTML] Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer

H Yang, Q Deng, T Ni, L Lu, H Dai… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Abstract Rationale: Nonalcoholic steatohepatitis (NASH), as one of the key stages in the
development of nonalcoholic fatty liver disease (NAFLD), can directly progress to HCC, but …

FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport

W Tian, W Zhang, Y Zhang, T Zhu, Y Hua, H Li… - Cancer Cell …, 2020 - Springer
Background The prognosis of colon cancer is poor for metastasis, while the mechanism,
especially adipocytes related, is not yet clear. The purpose of this study is to determine the …

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022

G Floresta, V Patamia, C Zagni, A Rescifina - European Journal of …, 2022 - Elsevier
The fatty acid binding protein 4 (FABP4) is a protein predominantly expressed in
macrophages and adipose tissue, where it regulates fatty acids storage and lipolysis and is …

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review

G Floresta, V Pistarà, E Amata, M Dichiara… - European journal of …, 2017 - Elsevier
Small molecule inhibitors of adipocyte fatty acid binding protein 4 (FABP4) have attracted
interest following the recent publications of beneficial pharmacological effects of these …

Milk's role as an epigenetic regulator in health and disease

BC Melnik, G Schmitz - Diseases, 2017 - mdpi.com
It is the intention of this review to characterize milk's role as an epigenetic regulator in health
and disease. Based on translational research, we identify milk as a major epigenetic …

Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enterica serovar Typhi CT18 reveal potential drug targets

R Debroy, SK Miryala, A Naha, A Anbarasu… - Microbial …, 2020 - Elsevier
Salmonella enterica subsp. enterica serovar Typhi, a human enteric pathogen causing
typhoid fever, developed resistance to multiple antibiotics over the years. The current study …

[HTML][HTML] Exploring the multi-drug resistance in Escherichia coli O157: H7 by gene interaction network: a systems biology approach

SK Miryala, S Ramaiah - Genomics, 2019 - Elsevier
In the present study, we have constructed an interaction network of 29 antibiotic resistant
genes along with 777 interactions in E. coli O157: H7. Gene ontology analysis reveals that …

[HTML][HTML] Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue

S Ponnusamy, QT Tran, I Harvey… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Most satiety-inducing obesity therapeutics, despite modest efficacy, have safety concerns
that underscore the need for effective peripherally acting drugs. An attractive therapeutic …