Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements
Epigenomic maps identify gene regulatory elements by their chromatin state. However,
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …
Cellular interactions in the pituitary stem cell niche
Stem cells in the anterior pituitary gland can give rise to all resident endocrine cells and are
integral components for the appropriate development and subsequent maintenance of the …
integral components for the appropriate development and subsequent maintenance of the …
Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles
Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET
Q Zhang, B Yao, X Long, Z Chen, M He, Y Wu… - Cell Reports …, 2023 - cell.com
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors with
variable recurrence rate. Currently, the recurrence prediction is unsatisfying and can be …
variable recurrence rate. Currently, the recurrence prediction is unsatisfying and can be …
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
Obesity alters levels of pituitary hormones that govern hepatic immune-metabolic
homeostasis, dysregulation of which leads to nonalcoholic fatty liver disease (NAFLD) …
homeostasis, dysregulation of which leads to nonalcoholic fatty liver disease (NAFLD) …
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis
We present a gene-level regulatory model, single-cell ATAC+ RNA linking (SCARlink),
which predicts single-cell gene expression and links enhancers to target genes using multi …
which predicts single-cell gene expression and links enhancers to target genes using multi …
[HTML][HTML] Multi-omics profiling of single nuclei from frozen archived postmortem human pituitary tissue
N Mendelev, M Zamojski, MAS Amper, WS Cheng… - STAR protocols, 2022 - Elsevier
Concomitant profiling of transcriptome and chromatin accessibility in isolated nuclei can
reveal gene regulatory control mechanisms in health and disease. We report a single …
reveal gene regulatory control mechanisms in health and disease. We report a single …
Transcriptomic and chromatin landscape analysis reveals that involvement of pituitary level transcription factors modulate incubation behaviors of magang geese
J Chang, D Fan, J Liu, Y Xu, X Huang, Y Tian, J Xu… - Genes, 2023 - mdpi.com
The incubation behavior of geese seriously affects their egg production performance.
Studies on incubation behavior have identified functional genes, but the regulatory …
Studies on incubation behavior have identified functional genes, but the regulatory …
Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary …
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …