In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

Sex differences in the genetic epidemiology and clinical features of psychiatric disorders are
well recognized, but the individual genes contributing to these effects have rarely been …

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

In humans, dopamine neurotransmission is influenced by functional polymorphisms in the
dopamine transporter (DAT 1) and catechol-O-methyltransferase (COMT) genes. Here, we …

Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of
dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to …

The enzyme catechol-O-methyl transferase (COMT), identified in the 1950s, is involved in
catabolism of monoamines that are influenced by psychotropic medications, including …

J. Neurochem.(2010) 114, 1745–1755. Abstract Catechol‐O‐methyltransferase (COMT)
plays an active role in the metabolism of dopamine (DA) in the prefrontal cortex (PFC) …

Reward processing depends on dopaminergic neurotransmission and is modulated by
factors affecting dopamine (DA) reuptake and degradation. We used fMRI and a guessing …

Parkinson's disease (PD)-mimicking drugs and pesticides, and more recently PD-associated
gene mutations, have been studied in cell cultures and mammalian models to decipher the …

Recent data from animal studies raise the possibility that dopaminergic neuromodulation
promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic …