The development of biomaterials for cardiac tissue engineering (CTE) is challenging,
primarily owing to the requirement of achieving a surface with favourable characteristics that …

Cell-based cardiac repair offers the promise of rebuilding the injured heart from its
component parts. Work began with committed cells such as skeletal myoblasts, but recently …

Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental
pathways. However, their roles in human cardiac precursor cell (CPC) remain unexplored …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Cell replacement therapy is a promising approach for the treatment of cardiac diseases, but
is challenged by a limited supply of appropriate cells. We have investigated whether …

Although myocyte cell transplantation studies have suggested a promising therapeutic
potential for myocardial infarction, a major obstacle to the development of clinical therapies …

When cultured in suspension without antidifferentiation factors, embryonic stem (ES) cells
spontaneously differentiate and form three-dimensional multicellular aggregates called …

Embryonic stem (ES) cells have been established as permanent lines of undifferentiated
pluripotent cells from early mouse embryos. ES cells provide a unique system for the genetic …

Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …

Objectives: The goal of this study was to guide bone marrow-derived human mesenchymal
stem cells (hMSCs) into a cardiac progenitor phenotype and assess therapeutic benefit in …