Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

Different types of synapses are specialized to interpret spike trains in their own way by virtue
of the complement of short-term synaptic plasticity mechanisms they possess. Numerous …

Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …

Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis.
Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

Synapses exhibit several forms of short-term plasticity that play a multitude of computational
roles. Short-term depression suppresses neurotransmitter release for hundreds of …