Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

M Messina, SB Mejia, A Cassidy… - Critical Reviews in …, 2022 - Taylor & Francis
Soybeans are a rich source of isoflavones, which are classified as phytoestrogens. Despite
numerous proposed benefits, isoflavones are often classified as endocrine disruptors, based …

Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME

Z Yang, K Kulkarni, W Zhu, M Hu - Anti-Cancer Agents in …, 2012 - ingentaconnect.com
Genistein, one of the most active natural flavonoids, exerts various biological effects
including chemoprevention, antioxidation, antiproliferation and anticancer. More than 30 …

Genistein: Its role in metabolic diseases and cancer

V Mukund, D Mukund, V Sharma, M Mannarapu… - Critical Reviews in …, 2017 - Elsevier
Genistein is an isoflavone present in soy and is known to have multiple molecular effects,
such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal …

Genistein: A focus on several neurodegenerative diseases

R Li, M Robinson, X Ding, T Geetha… - Journal of Food …, 2022 - Wiley Online Library
Neurodegenerative diseases are caused by the progressive loss of function or structure of
nerve cells in the central nervous system. The most common neurodegenerative diseases …

Cognitive effects of soy isoflavones in patients with Alzheimer's disease

CE Gleason, BL Fischer, NM Dowling… - Journal of …, 2015 - content.iospress.com
Background: In a previous trial, treatment with soy isoflavones was associated with improved
nonverbal memory, construction abilities, verbal fluency, and speeded dexterity compared to …

Risk assessment for peri‐and post‐menopausal women taking food supplements containing isolated isoflavones

EFSA Panel on Food Additives and Nutrient … - Efsa …, 2015 - Wiley Online Library
Abstract The EFSA ANS Panel was asked to deliver a scientific opinion on the possible
association between the intake of isoflavones from food supplements and harmful effects on …

The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats

B Šošić-Jurjević, D Lütjohann, K Renko… - The Journal of Steroid …, 2019 - Elsevier
We examined whether isoflavones interfere with thyroid homeostasis, increase hepatic
thyroid hormone concentrations and affect cholesterol metabolism in middle-aged (MA) …

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

Y Zhang, Q Li, D Zhou, H Chen - British Journal of Nutrition, 2013 - cambridge.org
The present study aimed to explore the role (s) of the soya isoflavone genistein (GEN) in
preventing the development of colon pre-neoplasia, using Wingless/int (WNT)/β-catenin as a …

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus–current status

P Ganesan, P Arulselvan, DK Choi - International journal of …, 2017 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and
it is characterized by an increase in blood glucose, disturbances in the metabolism, and …

Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor

MG Donovan, OI Selmin, TC Doetschman… - Nutrients, 2019 - mdpi.com
Triple negative breast cancers (TNBC) are the most aggressive and lethal breast cancers
(BC). The aryl hydrocarbon receptor (AHR) is often overexpressed in TNBC, and its …