Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian
survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3 …

Abstract The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental
but distinct cellular processes, endocytosis and autophagy, so its generation needs to be …

The fate of a cell is determined by multiple signaling pathways in response to a range of
stimuli. Probably the most prominent cell death mechanism is apoptosis which can be …

Autophagy is a process through which intracellular cargoes are catabolised inside
lysosomes. It involves the formation of autophagosomes initiated by the serine/threonine …

Autophagy is an evolutionarily conserved multistep degradation mechanism in eukaryotes,
that maintains cellular homoeostasis by replenishing cells with nutrients through catabolic …

Gastric cancer is the third most common cause of cancer-related death worldwide. Drug
resistance is the main inevitable and vital factor leading to a low 5-year survival rate for …

Abstract The Phosphatidylinositol-3-kinase (PI3K) family is well-known to comprise three
classes of intracellular enzymes. Class I PI3Ks primarily function in signaling by responding …

Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although
autophagy has been increasingly studied, how its process is precisely coordinated remains …