Since coumarin and hydroxamic acid compounds are well-known in medicinal chemistry, a
variety of their derivatives have been highlighted due to their potential uses for plentiful …

In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are
involved in the epigenetic regulation of gene expression. In the last decade, inhibition of …

Small cyclic peptides possess a wide range of biological properties and unique structures
that make them attractive to scientists working in a range of areas from medicinal to …

In the pasture of oncology, anticancer agents having advanced modes of action are of great
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …

Multi-targeted agents can interact with multiple targets sequentially, resulting in synergistic
and more effective therapies for several complicated disorders, including cancer, even with …

Tuberculosis is one of the main causes of morbidity and mortality across the globe.
Mycobacterium tuberculosis can attack any part of the human body and can cause …

A series of novel coumarin-based hydroxamate derivatives were designed and synthesized
as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC …