The role of ceramide metabolism and signaling in the regulation of mitophagy and cancer therapy
M Sheridan, B Ogretmen - Cancers, 2021 - mdpi.com
Simple Summary Sphingolipids are membrane-associated lipids that are involved in signal
transduction pathways regulating cell death, growth, and migration. In cancer cells …
transduction pathways regulating cell death, growth, and migration. In cancer cells …
Akt pathway inhibitors
NE Uko, OF Güner, DF Matesic… - Current topics in …, 2020 - ingentaconnect.com
Cancer is a devastating disease that has plagued humans from ancient times to this day.
After decades of slow research progress, promising drug development, and the identification …
After decades of slow research progress, promising drug development, and the identification …
[HTML][HTML] Eosinophilic esophagitis–linked calpain 14 is an IL-13–induced protease that mediates esophageal epithelial barrier impairment
BP Davis, EM Stucke, ME Khorki, VA Litosh, JK Rymer… - JCI insight, 2016 - ncbi.nlm.nih.gov
We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE)
at 2p23 spanning the calpain 14 (CAPN14) gene, yet the causal mechanism has not been …
at 2p23 spanning the calpain 14 (CAPN14) gene, yet the causal mechanism has not been …
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like …
Aim: The treatment of psoriasis remains elusive, underscoring the need for identifying novel
disease targets and mechanism-based therapeutic approaches. We recently reported that …
disease targets and mechanism-based therapeutic approaches. We recently reported that …
On the biological diversity of ant alkaloids
Ants have outstanding capacity to mediate inter-and intraspecific interactions by producing
structurally diverse metabolites from numerous secretory glands. Since Murray Blum's …
structurally diverse metabolites from numerous secretory glands. Since Murray Blum's …
Pharmacological potential of ants and their symbionts–a review
Abstract Ants (Hymenoptera: Formicidae) play an important role in the pharmacological and
food industry due to their therapeutic and nutritional properties. Being the most abundant …
food industry due to their therapeutic and nutritional properties. Being the most abundant …
Alkaloids solenopsins from fire ants display in vitro and in vivo activity against the yeast Candida auris
L Honorato, JJ Artunduaga Bonilla, L Ribeiro da Silva… - Virulence, 2024 - Taylor & Francis
The urgency surrounding Candida auris as a public health threat is highlighted by both the
Center for Disease Control (CDC) and World Health Organization (WHO) that categorized …
Center for Disease Control (CDC) and World Health Organization (WHO) that categorized …
RTN4 knockdown dysregulates the AKT pathway, destabilizes the cytoskeleton, and enhances paclitaxel-induced cytotoxicity in cancers
GP Pathak, R Shah, BE Kennedy, JP Murphy… - Molecular Therapy, 2018 - cell.com
Reticulon-4 (RTN4), commonly known as a neurite outgrowth inhibitor (Nogo), is emerging
as an important player in human cancers. Clinically, we found lower RTN4 expression in …
as an important player in human cancers. Clinically, we found lower RTN4 expression in …
[PDF][PDF] Effects of ceramide C2 application on human laryngeal carcinoma cells: a cell culture study
OBJECTIVE: In the present study, we investigated the effects of Ceramide C2 application on
human laryngeal carcinoma cells. MATERIALS AND METHODS: Human larynx epidermoid …
human laryngeal carcinoma cells. MATERIALS AND METHODS: Human larynx epidermoid …
[HTML][HTML] Inflammation and lymphedema are exacerbated and prolonged by neuropilin 2 deficiency
P Mucka, N Levonyak, E Geretti, BMM Zwaans… - The American journal of …, 2016 - Elsevier
The vasculature influences the progression and resolution of tissue inflammation.
Capillaries express vascular endothelial growth factor (VEGF) receptors, including …
Capillaries express vascular endothelial growth factor (VEGF) receptors, including …