Background Cognitive decline occurs frequently in Parkinson's disease (PD), which greatly
decreases the quality of life of patients. However, the mechanisms remain to be investigated …

Minocycline, a second-generation tetracycline antibiotic is being widely tested in animals as
well as clinical settings for the management of multiple neurological disorders. The drug has …

Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the
mitochondrial function, thus could increase the seizure susceptibility. Studies have shown …

Vincristine is an antineoplastic substance that is part of many chemotherapy regimens, used
especially for the treatment of a variety of pediatric cancers including leukemias and brain …

Although the anticonvulsant effects of ginsenosides are recognized, little is known about
their effects on the convulsive behaviors induced by the activation of L-type Ca 2+ channels …

Background and aims: Epilepsy is a neurological disorder causing brain dysfunctions.
Treatment and control of epilepsy have long been a challenge in medical sciences. Despite …

It is necessary to seek more effective sources to design new drug against epilepsy. This
study aimed to evaluate the effect of hydroalcoholic extract of Artemisia persica on …

Sepsis is a clinical syndrome with high morbidity and mortality. It is characterized by acute
inflammatory response and oxidative stress, which is implicated in cerebral dysfunction …

Abstract N-(2-hydroxyethyl) nicotinamide nitrate (nicorandil), a nitrate that activates
adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, is generally used in …

Cerebroneurovascular trauma is recognized as an important risk factor in the development
of seizure and epilepsy. Administration of citicoline in these situations is a conventional …