Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Background Traditionally, there has been a common belief that ongoing iv antibiotic therapy
is superior to an early iv to oral switch, especially for severe infections. However, this may be …

This study investigated aluminum-doped strontium nickel ferrite nanoparticles for
ciprofloxacin degradation under visible-light irradiation. XRD analysis confirmed the spinel …

Pharmacokinetic/pharmacodynamic (PKPD) models have emerged as valuable tools for the
characterization and translation of antibiotic effects, and consequently for drug development …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Augmented renal clearance (ARC) is a phenomenon of increased renal function in patients
with risk factors. Sub-therapeutic drug concentrations and antibacterial exposure in ARC …

The dramatic increase in antimicrobial resistance and the limited pharmacological treatment
options highlight the urgent need to optimize therapeutic regimens of new and available anti …

重症监护患者(ICU) 肾功能亢进(augmented renal clearance, ARC) 发生率高,
且由于此类患者常合并感染, ARC 的发生会使其对抗菌药物的清除率显著增加 …

Non-clinical antibiotic development relies on in vitro susceptibility and infection model
studies. Validating the achievement of the targeted drug concentrations is essential to avoid …

The optimal therapy for severe infections caused by vancomycin-resistant Enterococcus
faecium (VREfm) remains unclear, but the combination of linezolid and fosfomycin may be a …