The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …

Annotating cell types on the basis of single-cell RNA-seq data is a prerequisite for research
on disease progress and tumour microenvironments. Here we show that existing annotation …

Although the function of the mammalian pancreas hinges on complex interactions of distinct
cell types, gene expression profiles have primarily been described with bulk mixtures. Here …

Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …

RNA sequencing (RNA-Seq) uses the capabilities of high-throughput sequencing methods
to provide insight into the transcriptome of a cell. Compared to previous Sanger sequencing …

To understand organ function, it is important to have an inventory of its cell types and of their
corresponding marker genes. This is a particularly challenging task for human tissues like …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of
rare cellular states and uncover population heterogeneity, we performed single-cell RNA …