The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

There is a growing interest in developing microphysiological systems that can be used to
model both normal and pathological human organs in vitro. This “organs-on-chips” …

Current 3D printing of tissue is restricted by the use of biomaterials that do not recapitulate
the native properties of the extracellular matrix (ECM). These restrictions have thus far …

The unique physicochemical properties of materials at nanoscale have opened a plethora of
opportunities for applications in the pharmaceutical and medical field, but also in consumer …

More predictive in vitro liver models are a critical requirement for preclinical screening of
compounds demonstrating hepatotoxic liability. 3D liver spheroids have been shown to have …

Three-dimensional (3D) cultures are increasing in use because of their ability to represent in
vivo human physiology when compared to monolayer two-dimensional (2D) cultures. When …

Phosphopeptide enrichment is an essential step in large-scale, quantitative
phosphoproteomics by mass spectrometry. Several phosphopeptide affinity enrichment …

The major weakness of the current in vitro genotoxicity test systems is the inability of the
indicator cells to express metabolic enzymes needed for the activation and detoxification of …

In genetic toxicology, there is a trend against the increased use of in vivo models as
highlighted by the 3R strategy, thus encouraging the development and implementation of …

Introduction: Human pluripotent stem cells (hPSCs) provide many opportunities for
application in regenerative medicine due to their ability to differentiate into cells from all …