The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

Migraine is a complex neurological disorder and a major cause of disability. A wide range of
different drug classes such as triptans, antidepressants, anticonvulsants, analgesics, and …

DNA methylation is a key epigenetic modification to regulate gene expression in mammalian
cells. Abnormal DNA methylation in gene promoters is common across human cancer types …

DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …

How fetal brain development is regulated at the molecular level is not well understood. Due
to ethical challenges associated with research on the human fetus, large animals particularly …

Purpose Overactivated neddylation is considered to be a common event in cancer. Long
non-coding RNAs (lncRNAs) can regulate cancer development by mediating post …

As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG
methylation-mediated disruption of alternative splicing is increasingly recognized as a driver …

Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional
regulation. APA can impact the development and progression of cancer, suggesting that the …

The Long-read POG dataset comprises a cohort of 189 patient tumours and 41 matched
normal samples sequenced using the Oxford Nanopore Technologies PromethION platform …

Background Dual antiplatelet therapy with clopidogrel and aspirin is the primary treatment
for patients who undergo percutaneous coronary intervention. However, the interindividual …