Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Currently, cancer and its progression to metastasis result in a large number of deaths. The
lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete …

Thiazole derivatives are recognized to possess various biological activities as antiparasitic,
antifungal, antimicrobial and antiproliferative. The present work reports the synthesis of 22 …

In the search for new antifungal agents, a novel series of fifteen hydrazine-thiazole
derivatives was synthesized and assayed in vitro against six clinically important Candida …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

In this work, the binding affinity of fanetizole with proteases pepsin and trypsin were
investigated by spectroscopy and molecular docking. As a thiazole derivative, the …

Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan
parasite that causes Chagas disease. Encoded by a multigenic family, previous studies …

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …