Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The seminal hypotheses proposed over the years for enzymatic catalysis are scrutinized.
The historical record is explored from both biochemical and theoretical perspectives …

Currently the Protein Data Bank (PDB) contains over 25 000 structures that contain a metal
ion including Na, Mg, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Pd, Ag, Cd, Ir, Pt, Au, and Hg. In …

Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …

Metallo-β-lactamases are broad-spectrum zinc enzymes, able to inactivate most clinically
useful β-lactam antibiotics. Their structural and functional diversity has thus far limited the …

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are
last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

The design of inhibitors against metallo-β-lactamases (MBLs), the largest family of
carbapenemases, has been a strategic goal in designing novel antimicrobial therapies. In …

A fundamental postulate in the classical drug design paradigm is that the effect of a drug in
the human body is a consequence of the molecular recognition between a ligand (the drug) …

ABSTRACT Taniborbactam (TAN; VNRX-5133) is a novel bicyclic boronic acid β-lactamase
inhibitor (BLI) being developed in combination with cefepime (FEP). TAN inhibits both serine …