Aptamers have become coming-of-age molecular recognition elements in both diagnostic
and therapeutic applications. Generated by SELEX, the 'quality control'of aptamers, which …

Bidirectional cell–cell communication involving exosome-borne cargo such as miRNA has
emerged as a critical mechanism for wound healing. Unlike other shedding vesicles …

The photonic characteristics of chromophore-containing metal-organic frameworks (MOFs)
have led to extensive photophysical studies in an effort to capitalize on the potency of …

Emission fluorescence is one of the most versatile and powerful biophysical techniques
used in several scientific subjects. It is extensively applied in the studies of proteins, their …

Simvastatin is a top-selling cholesterol-lowering drug traditionally obtained through a semi-
synthetic process starting from lovastatin. However, this process is cost-demanding and …

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis,
propensity for early metastasis and resistance to chemotherapy. Little is known about the …

The formation of macromolecular complexes can be measured by detection of changes in
rotational mobility using time-resolved fluorescence anisotropy. However, this method is …

Life may be expressed as the flow of electrons, protons, and other ions, resulting in large
potential difference. It is also highly photo-sensitive, as a large proportion of the redox …

Mitochondrial aconitase (ACO2) has been postulated as a redox sensor in the tricarboxylic
acid cycle. Its high sensitivity towards reactive oxygen and nitrogen species is due to its …

Native electrospray ionization (ESI) and nanoelectrospray ionization (nESI) allow
researchers to analyze intact biomolecules and their complexes by mass spectrometry (MS) …