The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …

Cells sense their environment and adapt to it by fine-tuning their transcriptome. Wired into
this network of gene expression control are mechanisms to compensate for gene dosage …

Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited
by the time required to generate stable mutant lines. We describe a system for gene …

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

The zebrafish (Danio rerio) has emerged as a powerful model to study vertebrate
development and disease. Its short generation time makes it amenable to genetic …

The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has
radically changed targeted mutagenesis. Here, we present a high-throughput targeted …

The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …