Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …

Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key
therapeutic target. Although initially effective, the generation of alternatively spliced AR …

HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the
differentiation of the prostate gland. Several studies have suggested that HOXB13 …

Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively
activating variant of androgen receptor (AR), is considered as the key driver to initiate …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Simple Summary Androgen receptor splice variant 7 (AR-V7) has always been considered a
key driver for triggering enzalutamide resistance of castration-resistant prostate cancer …

Chemotherapy predominates in clinical treatment of prostate cancer (PCa), while
irreversible resistance to chemotherapeutics and severe side effects hinder the therapeutic …

Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …