Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair
TL Scott, S Rangaswamy, CA Wicker… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Reactive oxygen species (ROS) are generated by exogenous and
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …
Repair of oxidatively induced DNA damage by DNA glycosylases: mechanisms of action, substrate specificities and excision kinetics
Endogenous and exogenous reactive species cause oxidatively induced DNA damage in
living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or …
living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or …
Thirdhand smoke causes DNA damage in human cells
Exposure to thirdhand smoke (THS) is a newly described health risk. Evidence supports its
widespread presence in indoor environments. However, its genotoxic potential, a critical …
widespread presence in indoor environments. However, its genotoxic potential, a critical …
The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection
Abstract SARS-CoV-2 infection-induced aggravation of host innate immune response not
only causes tissue damage and multiorgan failure in COVID-19 patients but also induces …
only causes tissue damage and multiorgan failure in COVID-19 patients but also induces …
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis
A Chatterjee, S Saha, A Chakraborty… - PLoS …, 2015 - journals.plos.org
DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation,
oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) …
oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) …
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation*♦
A Chakraborty, M Wakamiya… - Journal of Biological …, 2015 - ASBMB
Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate
ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway …
ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway …
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells
Infection with the Gram-negative, microaerophilic bacterium Helicobacter pylori induces an
inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to …
inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to …
The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells
Colorectal cancer (CRC) is the third most prevalent cancer, while the majority (80–85%) of
CRCs are sporadic and are microsatellite stable (MSS), and approximately 15–20% of them …
CRCs are sporadic and are microsatellite stable (MSS), and approximately 15–20% of them …
PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair …
We find that PEG functionalized ZnO nanoparticles (NP) have anticancer properties primarily
because of ROS generation. Detailed investigation revealed two consequences depending …
because of ROS generation. Detailed investigation revealed two consequences depending …
DNA damage in chronic kidney disease: evaluation of clinical biomarkers
N Schupp, H Stopper, A Heidland - Oxidative medicine and …, 2016 - Wiley Online Library
Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a
healthy control population. To be able to estimate the cancer risk of the patients and to …
healthy control population. To be able to estimate the cancer risk of the patients and to …