Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

The Btg family of anti-proliferative gene products includes Pc3/Tis21/Btg2, Btg1, Tob, Tob2,
Ana/Btg3, Pc3k and others. These proteins are characterized by similarities in their amino …

The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key
regulators of insulin signaling, cell cycle progression, and apoptosis downstream of …

Treatment with chemotherapy or radiation is not invariably cytotoxic to all tumor cells. Some
of the cells that survive treatment recover and resume proliferation, whereas others undergo …

We present genome-wide microarray expression analysis of 11,000 genes in an aging
potentially mitotic tissue, the liver. This organ has a major impact on health and homeostasis …

More than two-thirds of breast cancers express the estrogen receptor (ER) and depend on
estrogen for growth and survival. Therapies targeting ER function, including aromatase …

Abstract PC3TIS21/BTG2 is the founding member of a family of genes endowed with
antiproliferative properties, namely BTG1, ANA/BTG3, PC3B, TOB, and TOB2. PC3 was …

Chemical exposure of cells may damage biomolecules, cellular structures, and organelles
thereby jeopardizing cellular homeostasis. A multitude of defense mechanisms have …

Purpose: The purpose of this study is to define the mechanistic basis for recovery of
proliferative capacity in breast tumor cells after chemotherapy. Here, we test the hypothesis …

tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous
formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher …