Fluoroquinolones tackling antimicrobial resistance: Rational design, mechanistic insights and comparative analysis of norfloxacin vs ciprofloxacin derivatives

A Khanna, N Kumar, R Rana, A Sharma, H Kaur… - Bioorganic …, 2024 - Elsevier
Antimicrobial resistance poses a global health concern and develops a need to discover
novel antimicrobial agents or targets to tackle this problem. Fluoroquinolone (FN), a DNA …

[HTML][HTML] Quinolin-4-ones: Methods of Synthesis and Application in Medicine

K Gach-Janczak, J Piekielna-Ciesielska, J Waśkiewicz… - Molecules, 2025 - mdpi.com
Quinolinones, also called quinolones, are a group of heterocyclic compounds with a broad
spectrum of biological activities. These compounds occur naturally in plants and …

Advances in the Synthesis and Chemistry of Arylhydrazonals Derivatives as Key Players in Medicinal Chemistry and Biological Science

MR Eletmany, IM Abdellah - Chelonian Research Foundation, 2023 - acgpublishing.com
This review analyses the chemical characteristics of arylhydrazonals in depth, with a
particular emphasis on their critical function in heterocyclic synthesis. Arylhydrazonals are …

Design, synthesis and docking studies of ciprofloxacin analogues as potential antimicrobial agents against resistant pathogens

I Rehman, S Gul, M Akhtar, R Amin - Journal of Molecular Structure, 2024 - Elsevier
Antibiotic resistance is one of the leading fears worldwide. Development of resistance
against antimicrobial agents is one of the major purposes for research and development of …

Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines

N Ferrario, E Marras, V Vivona, F Randisi, AN Fallica… - Cancers, 2024 - mdpi.com
Antibacterial fluoroquinolones have emerged as potential anticancer drugs, thus prompting
the synthesis of novel molecules with improved cytotoxic characteristics. Ciprofloxacin and …

Photoisomerization and Light‐Controlled Antibacterial Activity of Fluoroquinolone‐Azoisoxazole Hybrids

A Dolai, S Bhunia, SK Jana, S Bera, S Mandal… - …, 2024 - Wiley Online Library
Photopharmacology holds a huge untapped potential to locally treat diseases involving
photoswitchable drugs via the elimination of drugs' off‐target effects. The growth of this field …

Novel quinolone substituted 1, 3, 4-oxadiazole derivatives: design, synthesis, antimicrobial and anti-inflammatory potential

V Sharma, R Das, DK Mehta, D Sharma - Molecular Diversity, 2024 - Springer
A novel series of quinolone-substituted 1, 3, 4-oxadiazole derivatives 4 (a–l) have been
designed and synthesized. The target compounds were investigated for their antibacterial …

A Novel Process for the Key Intermediate of Fluoroquinolones

K Yin, X Yin, W Wu, H Wu, X He… - Organic Preparations and …, 2024 - Taylor & Francis
Fluoroquinolones (FQs) are a group of second-generation, broad-spectrum antibiotics.
Among them, enrofloxacin (ENR, Figure 1), has the characteristics of a wide antibacterial …

[PDF][PDF] Trifluoroacetyl-Substituted Quinolones as New Antibacterials Against Antibiotic Resistant Strains

D Hodyna, A Klipkov, Y Shulha, N Shevchenko… - 2024 - nanobioletters.com
This article describes the design of a series of new trifluoroacetyl-substituted quinolones,
synthesis, and characterization by 1H and 19F NMR, mass spectroscopy, and their …

Antimicrobial resistance: mechanisms and ways to combat.

V PANTYO, E DANKO, G KOVAL - 2024 - dspace.uzhnu.edu.ua
Antibiotics play a key role in treatment and controlling bacterial infections. Resistance to
antibiotics that are widely used in clinical practice is the global unsolved problem of …