Fluoroquinolones tackling antimicrobial resistance: Rational design, mechanistic insights and comparative analysis of norfloxacin vs ciprofloxacin derivatives
Antimicrobial resistance poses a global health concern and develops a need to discover
novel antimicrobial agents or targets to tackle this problem. Fluoroquinolone (FN), a DNA …
novel antimicrobial agents or targets to tackle this problem. Fluoroquinolone (FN), a DNA …
[HTML][HTML] Quinolin-4-ones: Methods of Synthesis and Application in Medicine
K Gach-Janczak, J Piekielna-Ciesielska, J Waśkiewicz… - Molecules, 2025 - mdpi.com
Quinolinones, also called quinolones, are a group of heterocyclic compounds with a broad
spectrum of biological activities. These compounds occur naturally in plants and …
spectrum of biological activities. These compounds occur naturally in plants and …
Advances in the Synthesis and Chemistry of Arylhydrazonals Derivatives as Key Players in Medicinal Chemistry and Biological Science
MR Eletmany, IM Abdellah - Chelonian Research Foundation, 2023 - acgpublishing.com
This review analyses the chemical characteristics of arylhydrazonals in depth, with a
particular emphasis on their critical function in heterocyclic synthesis. Arylhydrazonals are …
particular emphasis on their critical function in heterocyclic synthesis. Arylhydrazonals are …
Design, synthesis and docking studies of ciprofloxacin analogues as potential antimicrobial agents against resistant pathogens
Antibiotic resistance is one of the leading fears worldwide. Development of resistance
against antimicrobial agents is one of the major purposes for research and development of …
against antimicrobial agents is one of the major purposes for research and development of …
Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines
N Ferrario, E Marras, V Vivona, F Randisi, AN Fallica… - Cancers, 2024 - mdpi.com
Antibacterial fluoroquinolones have emerged as potential anticancer drugs, thus prompting
the synthesis of novel molecules with improved cytotoxic characteristics. Ciprofloxacin and …
the synthesis of novel molecules with improved cytotoxic characteristics. Ciprofloxacin and …
Photoisomerization and Light‐Controlled Antibacterial Activity of Fluoroquinolone‐Azoisoxazole Hybrids
Photopharmacology holds a huge untapped potential to locally treat diseases involving
photoswitchable drugs via the elimination of drugs' off‐target effects. The growth of this field …
photoswitchable drugs via the elimination of drugs' off‐target effects. The growth of this field …
Novel quinolone substituted 1, 3, 4-oxadiazole derivatives: design, synthesis, antimicrobial and anti-inflammatory potential
A novel series of quinolone-substituted 1, 3, 4-oxadiazole derivatives 4 (a–l) have been
designed and synthesized. The target compounds were investigated for their antibacterial …
designed and synthesized. The target compounds were investigated for their antibacterial …
A Novel Process for the Key Intermediate of Fluoroquinolones
K Yin, X Yin, W Wu, H Wu, X He… - Organic Preparations and …, 2024 - Taylor & Francis
Fluoroquinolones (FQs) are a group of second-generation, broad-spectrum antibiotics.
Among them, enrofloxacin (ENR, Figure 1), has the characteristics of a wide antibacterial …
Among them, enrofloxacin (ENR, Figure 1), has the characteristics of a wide antibacterial …
[PDF][PDF] Trifluoroacetyl-Substituted Quinolones as New Antibacterials Against Antibiotic Resistant Strains
This article describes the design of a series of new trifluoroacetyl-substituted quinolones,
synthesis, and characterization by 1H and 19F NMR, mass spectroscopy, and their …
synthesis, and characterization by 1H and 19F NMR, mass spectroscopy, and their …
Antimicrobial resistance: mechanisms and ways to combat.
V PANTYO, E DANKO, G KOVAL - 2024 - dspace.uzhnu.edu.ua
Antibiotics play a key role in treatment and controlling bacterial infections. Resistance to
antibiotics that are widely used in clinical practice is the global unsolved problem of …
antibiotics that are widely used in clinical practice is the global unsolved problem of …