The Fontan operation was first performed in 1968. Since then, this operation has been
performed on thousands of patients worldwide. Results vary from very good for many …

Over the past decade, as the majority of patients with single ventricle anatomy who have
undergone the Fontan operation reach adulthood, a newly recognized disease process …

2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A
Report of the American College of Cardiology/American Heart Association Task Force on …

Pulmonary hypertension (PH) in neonates, infants, children, adolescents, and young adults
is a complex condition that can be associated with several cardiac, pulmonary, and systemic …

Background—The Fontan procedure has improved survival in children with functionally
univentricular hearts. With time, however, complications such as reduced exercise capacity …

Background: Patients with protein-losing enteropathy (PLE) following the Fontan operation
have a reported 50% mortality at 5 years after diagnosis. Objectives: The aim of this study …

A normal mammalian cardiovascular system consists of a double circuit, pulmonary and
systemic, connected in series and powered by a double pump. In the absence of congenital …

Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

Background: The Fontan operation creates a total cavopulmonary connection, a circulation
in which the importance of pulmonary vascular resistance is magnified. Over time, this …

Background—Patients with Fontan circulation have reduced exercise capacity. The absence
of a presystemic pump may limit flow through the pulmonary circulation, restricting …