Neuropathology and molecular diagnosis of Synucleinopathies
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
[HTML][HTML] Phase separation and neurodegenerative diseases: a disturbance in the force
A Zbinden, M Pérez-Berlanga, P De Rossi… - Developmental cell, 2020 - cell.com
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …
features, with α-synuclein pathology as the gold standard to establish the definitive …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about
the clinical and pathologic diagnosis of DLB, updating the previous report, which has been …
the clinical and pathologic diagnosis of DLB, updating the previous report, which has been …
Impact of multiple pathologies on the threshold for clinically overt dementia
Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …
Mini‐Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations
ST Creavin, S Wisniewski… - Cochrane Database …, 2016 - cochranelibrary.com
Background The Mini Mental State Examination (MMSE) is a cognitive test that is commonly
used as part of the evaluation for possible dementia. Objectives To determine the diagnostic …
used as part of the evaluation for possible dementia. Objectives To determine the diagnostic …
Cognitive training for people with mild to moderate dementia
Background Cognitive impairment, a defining feature of dementia, plays an important role in
the compromised functional independence that characterises the condition. Cognitive …
the compromised functional independence that characterises the condition. Cognitive …
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy …
A Van der Perren, G Gelders, A Fenyi, L Bousset… - Acta …, 2020 - Springer
Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and
dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) …
dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) …
Dementia with Lewy bodies: an update and outlook
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder
producing progressive cognitive decline that interferes with normal life and daily activities …
producing progressive cognitive decline that interferes with normal life and daily activities …