Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review

S Alfei, F Turrini, S Catena, P Zunin, M Grilli… - European journal of …, 2019 - Elsevier
It is well-known that the health properties attributed to several fruits, herbs, seeds and their
processed foods/beverages are due to an important group of natural polyphenols classified …

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

S Liu, M Fan, JX Xu, LJ Yang, CC Qi, QR Xia… - Journal of …, 2022 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by a
progressive decline in cognitive ability. Exosomes derived from bone-marrow mesenchymal …

Role of the cholinergic anti-inflammatory reflex in central nervous system diseases

IE Ramos-Martínez, MC Rodríguez, M Cerbón… - International Journal of …, 2021 - mdpi.com
In several central nervous system diseases, it has been reported that inflammation may be
related to the etiologic process, therefore, therapeutic strategies are being implemented to …

Sex differences in depression and anxiety

P Pavlidi, N Kokras, C Dalla - Sex Differences in Brain Function and …, 2022 - Springer
Depression and anxiety disorders carry a tremendous worldwide burden and emerge as a
significant cause of disability among western societies. Both disorders are known to …

Forebrain cholinergic signaling regulates innate immune responses and inflammation

KR Lehner, HA Silverman, ME Addorisio… - Frontiers in …, 2019 - frontiersin.org
The brain regulates physiological functions integral to survival. However, the insight into
brain neuronal regulation of peripheral immune function and the neuromediator systems …

Neuroinflammation in Alzheimer's disease and beneficial action of luteolin

A Delgado, C Cholevas, TC Theoharides - Biofactors, 2021 - Wiley Online Library
Abstract Alzheimer's disease (AD), already the world's most common form of dementia, is
projected to continue increasing in prevalence over the next several decades. The current …

Acetylcholine regulates pulmonary pathology during viral infection and recovery

AP Horkowitz, AV Schwartz, CA Alvarez… - ImmunoTargets and …, 2020 - Taylor & Francis
Introduction This study was designed to explore the role of acetylcholine (ACh) in pulmonary
viral infection and recovery. Inflammatory control is critical to recovery from respiratory viral …

Alzheimer disease treatment with acetylcholinesterase inhibitors and incident age-related macular degeneration

SS Sutton, J Magagnoli, TH Cummings… - JAMA …, 2024 - jamanetwork.com
Importance Age-related macular degeneration (AMD) is a serious and common
ophthalmologic disorder that is hypothesized to result, in part, from inflammatory reactions in …

Alterations in immune responses are associated with dysfunctional intracellular signaling in peripheral blood mononuclear cells of men and women with mild cognitive …

R Vasantharekha, HP Priyanka, RS Nair, L Hima… - Molecular …, 2024 - Springer
Deficits in the neuroendocrine-immune network in the periphery associated with the onset
and progression of mild cognitive impairment (MCI) and Alzheimer's disease (AD) have not …

Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis

R Giacconi, C Giuli, T Casoli, M Balietti… - Journal of Trace …, 2019 - Elsevier
Background Alzheimer's disease (AD) is the most common age-related neurodegenerative
disease. An altered homeostasis of Zinc (Zn) and Copper (Cu), as well as a dysregulated …